Poster Index

Genetic, epigenetic and gene expression contributors to suicide risk

Clinical and neurocognitive studies of suicidal behavior (17)  |  Clinical phenotyping of suicidal individuals (23)
Culture, ethnicity and spiritual approaches. New paradigms in suicidology (11)  |  Ethical and methodological challenges and solutions in suicide research (5)
Genetic, epigenetic and gene expression contributors to suicide risk (2)  |  Intervention research for prevention of suicidal behavior (30)
Lifespan differential aspects (from infancy to elderly) (7)  |  Miscellany (assisted suicide, minorities, legal aspects, etc.) (9)
Neurobiological underpinnings of suicidal behavior (3)  |  Novel monitoring strategies for detecting changes in risk over time (4)
Psychosocial variables: protective and risk factors. Resilience & vulnerability (38)  |  Testing the effectiveness of prevention strategies (6)




Genetic, epigenetic and gene expression contributors to suicide risk


(386) PO-386. Are Single Nucleotide Polymorphisms within SKA2, OPRM1 and KOR genes linked to suicidal behavior?

Day: 09 | Time: 10:30 | Room: Poster Hall

Topic: Genetic, epigenetic and gene expression contributors to suicide risk

Authors:Bénédicte Nobile . Department of Emergency Psychiatry and Post Acute Care, Hôpital Lapeyronie, CHU Montpellier, Montpellier - France
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 Introduction:
Suicide is a major public health problem and news therapeutics target and genetic markers could help to improve the care of patients. Opioidergic system seems to be implicated in the physiopathology of suicide but mechanisms are still unclear.
 Goals:
The aim of our study is firstly to find genetic markers of suicidal behavior and secondly to find a link between single nucleotide polymorphisms of those genes and response to treatment.
 Methodology:
This is a retrospective study on a cohort of 3771 patients with a major depressive episode according to the DSM-IV criteria. Those patients were treated with Tianeptine during six weeks. They were screened on suicidal thoughts and behaviors. They were also screened on depressive symptomatology and impulsivity (MADRS, HAD scale and Plutchik questionnary, both hetero and self evaluation at zero and six weeks and another self evaluation at two and four weeks). For genotyping we used genomic DNA purified from blood patients. We did a qPCR with Taqman® technical and analysed scatter plot for results.
 Results:
Assays pending
 Conclusions:
We expect a positive correlation between suicidal behavior and some single nucleotide polymorphisms of those genes.
 References:
1. AB Niculescu, DF Levey, PL Phalen, H Le-Niculescu1, HD Dainton, N Jain, E Belanger, A James, S George, H Weber, DL Graham, R Schweitzer, TB Ladd, R Learman, EM Niculescu, NP Vanipenta, FN Khan, J Mullen, G Shankar, S Cook, C Humbert, A Ballew, M Yard, T Gelbart, A Shekhar, NJ Schork, SM Kurian, GE Sandusky and DR Salomon; Understanding and predicting suicidality using a combined genomic and clinical risk assessment approach; Molecular Psychiatry (2015) 20, 1266–1285; doi:10.1038/mp.2015.112; published online 18 August 2015
2. Mark A. Ilgen, Amy S. B. Bohnert, Dara Ganoczy, Matthew J. Bair, John F. McCarthy, Frederic C. Blow; Opioid dose and risk of suicide; PAIN Publish Ahead of Print DOI: 10.1097/j.pain.0000000000000484


(388) PO-388. Genes and risk of suicide: A systematic review of studies.

Day: 10 | Time: 13:30 | Room: Poster Hall

Topic: Genetic, epigenetic and gene expression contributors to suicide risk

Authors:Laura Rubio Rodriguez . Hospital de Jove/ Hospital de Cabueñes, Gijón - Spain
- Miguel Maldonado Fernandez - Jorge Antolin Suarez - Danny Francisco Frias Ortiz -

 Introduction:
Suicide is a major preventable health problem that can have prolonged harmful effects on individuals, families, and communities. The main object of suicide prevention is to remove the risk factors. The number of genetic variations that have been related to an increased risk of suicide is continuously increasing.
 Goals:
To summarize in a systematic way the current evidence on the genetic variations related to an increased risk of suicidal behaviour, understood as suicide attempts or consummated suicide.
 Methodology:
A systematic review of studies on genetic alterations related with risk of suicidal behaviour.
 Results:
We found 240 articles our primary search. We selected 196 articles that looked into the role of genes in an increased risk of suicidal behaviour.
 Conclusions:
We carried out a comprehensive systematic review to resume the current situation of genetic disorders related to suicidal behaviour. We expect this review to be a useful tool to summarize the evidence on this subject.
 References:
1. Centers for Disease Control and Prevention. Suicide Prevention. Available online at [http://www.cdc.gov/violenceprevention/suicide/]. 2. Higgins JPT, Green S (editors). Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 [updated March 2011]. The Cochrane Collaboration, 2011. Available from http://handbook.cochrane.org.